الدكتور/عبدالرحمن بن خازم ناصر الأسمري

ولد في بللسمر قرية ذبوب عام 1381هـ/ 1961م

درس الإبتدائي والمتوسط والثانوي في بللسمر ثم ألتحق بجامعة الملك سعود (الرياض سابقاُ) بكلية الصيدلة وتخرج منها وحصل على بعثة لتكملة الماجستير والدكتوراه وحصل على الدكتوراه في المناعة ،

.وهو عضو في العديد من الجمعيات الطبية في العالم .

نائب مدير مركز الأبحاث

بمستشفى القوات المسلحة بالرياض

المؤهلات:

دكتوراه في السموم المناعية -

بريطانيا .

ماجستير في علم السموم -

جامعة الملك سعود .

دبلوم في التلوث البيئي - أمريكا .

دبلوم في دراسة حركية الأدوية

والسموم - كندا .

لمزيداً من المعلومات أنظر في السيرة الذاتية باللغة الإنجليزية

CURRICULUM VITA

PERSONAL DETAILS:

Name: Dr Abdulrahman Khazim Al-Asmari

Nationality: Saudi

Date of birth: 1961

Position: Consultant Toxinologist (immuno-toxicologist) and deputy head of Research Center, Riyadh Military Hospital.

Address: Research Center, Riyadh Military Hospital, Saudi Arabia. P.O.box.7897(775s). E.mail: akasmari@medu.net.sa

EDUCATION AND WORK EXPERIENCE

2002. Molecular Biology course in King Fisal Specialist Hospital

2001. Clinical Toxinology Short Course. Adelaide Universitry Faculty of Health Science. Australia.

Jan. 1997: I joined the research center in Riyadh Military Hospital until present time. Primarily I started developing a rapid diagnostic assay using double sandwich ELISA which can be used to identify venomous snake species and to measure the level of venom antigens in biological samples (plasma and urine).

Secondly studying the pharmacokinetics of Saudi Arabian snake venom’s and their available antivenoms using rabbits. Aiming to provide a better understanding of the pharmacokinetic aspects of snake envenomation in man.

(28.12.1993 to 31.2.1997): I was awarded scholarship to obtain Ph.D in UK on the development of specific ovine antivenoms against venomous snakes in Saudi Arabia. This work was carried out at the Chemical Pathology, Medical College of Saint Basrtholomews Hospital, London, UK. Under the supervision of Professor John Landon. I was awarded Ph.D in 31.2.1997. During the course of this study, I participated in a number of conferences and attended various scientific meetings and symposia. This study utilized the academic knowledge and research experience in the areas of Immunology, Biochemistry, Toxicology and Pharmacology. I development specific antivenoms for Saudi Arabian venomous snakes. The work based on production and characterisation of seven therapies namely those for Echis carinatus, Echis coloratus, Bitis arietans, Cerastes cerastes, Naja haje arabica, W. aegyptia and Atractaspis microlepidota envenoming.

The programme include:

Characterising venoms using SDS PAGE, FPLC/HPLC, LD5o.

Development of in vitro assays for important venom activities (Via WHO-mandate on production of antivenoms).

Comparison of venom activities with WHO reference samples from

Liverpool School of Tropical Medicine.

Immunisation protocol development and primary sheep immunisation.

Primary antisera assessment. ELISA, IEP, RIA, IA SDS PAGE.

Antiserum processing. Production of IgG, F(ab)² and Fab fragments

using TAb methodology. This included visits to TAb Wales

In vitro antivenom assessment using enzymatic and biological assays.
Inyivo ED_5o assessment of antivenoms produced during the study.

Quality control studies include the purity, efficacy and safety of the antivenoms
produced.

Complete the work in other laboratories:

(i) In vivo assessment of antivenoms - Liverpool School of Tropical Medicine.
(ii) Large scale antivenom production methods and QC - TAb Wales
(iii) Discussions on the set up and implementation of clinical trials in Saudi Arabia
with Prof. D. Warrell (Oxford University)

1993. Radiation Protection Training Course. The topics covered included:

The use of raditation monitring instruments and dosemeters. Personal dosimetery

Rules and regulations (requirements of the IRR and RSA

Safe working with radioactive materials

Waste disposal and record keeping.

1992/93: Diploma in environmental Pollution Research at the National Institute of Standards and Technology, Maryland, USA. I was associated with several research projects in the field of environmental Pollution in Saudi Arabia especially the detection and quantitation of the pollution caused by industrial chemical like aromatic hydrocarbons, asbestos, and heavy metals.

1992: Completed specialized course in Methods of Scientific Research College of Health Science, State of Bahrain.

1991: MSc. in Toxicology from Pharmacy College, King Saud University, Riyadh.

1987: Joined the Drug Information and Poisoning Center at Riyadh Military Hospital.

1986: Awarded a scholarship in Clinical Pharmacy from London Royal Hospital, UK.

1983-1985: Clinical Pharmacist at King Abdulaziz Hospital in Dhahran.

1983: Qualified from Pharmacy College (Bacholar), King Saud University, Riyadh.

Publications

Al-Asmari, A. K., Bekairi, A. M. and Ageel, A. M. 1988. Effect of caffeine on ethanol induced spermatogenic dysfunction in murine germ cells. International Narcotics Research Conference, Center Cultural, Albi (France).

Al- Asmari, A. K., Islam, M. W. and M. Tariq. 1990. Studies on deleterious effects of alcohol, nicotine and their combination on pregnancy, in rats. FASEB Experimental Biology Meeting, Washington DC.

Ageel, A. M., Tariq, M. and Al-Asmari, A. K. 1990. Pre-natal and post-natal development of Wister Albino Rats, following maternal exposure to alcohol and nicotine individually and in combination. 17th Congress of Collegium International Neuro-psychpharmacologicum. Akasaka, Minato-Ku Tokyo, Japan.

Ageel, A. M., Al-Asmari, A. K. and Tariq, M. 1990. Effect of maternal alcohol and nicotine consumption on growth and development of offsprings. 17th congress of Collegium International Neuro-psychpharmacologicum. Akasaka, Minato-Ku Tokyo, Japan.

Al- Asmari A. K. 1991. Effect of nicotine on ethanol induced spermatogenic dysfunction in murine germ cells. Toxicological Problems, Drug Information and Clinical Pharmacology, Jeddah, Saudi Arabia.

Wilkinson, o. and Al-Asmari A. k. 1991. Extrapyramidal reactions to dompridone in infants and analysis of dompridone in serum by HPLC. Toxicological problems, Drug Information and Clinical Pharmacology, Jeddah, Saudi Arabia.

Al- Asmari A. K. 1991. Toxicity studies of concurrent use of alcohol, caffeine and nicotine on some aspects of reproduction. MSc in Pharmaceutical Science (Toxicology), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Al-Asmari A. K. and Al- Nasser I. 1993. Physicians Attitudes towards the use of clinical pharmaceutical services in Riyadh Military Hospital. ASHP, Atlanta, Georgia, USA.

Al- Asmari A. K. and Al-Nasser I. 1993. Environmental pollution in Saudi Arabia. Symposium in polycyclic Aromatic Compounds. Missouri, USA.

Al- Asmari A. K. 1994. Venomous snakes in Saudi Arabia. William Harvey Day, Chemical Pathology, Medical College of Saint Barts, London, UK.

Abdulrahman k. Al-Asmari, Ibrahim Al-Abdullah, Ray G. Crouch, Damon C. Smith, and Lena Sjostrom. (1995). Assessment of an ovine antivenom raised against venom from the desert black cobra (Walternnesia aegyptia). Abstract. International Symposium on Paris, Toxinology Society

Abdulrahman k. Al-Asmari. (1995). Assessment of an ovine antivenom raised against venom from common Vipers (E. carinatus, E.coloratus, B.arietans, C.cerastes) in Saudi Arabia. International Symposium on Wales, British venom group.

Abdulrahman k. Al-Asmari, 1996. Production and Assessment of specific ovine antivenoms against the most venomous snakes in Saudi Arabia. Ph.D. Thesis, Medical College of Saint Barts, London,UK.

Abdulrahman k. Al-Asmari, Ibrahim Al-Abdullah, Ray G. Crouch, Damon C. Smith, and Lena Sjostrom. (1997). Assessment of an ovine antivenom raised against venom from the desert black cobra (Walternnesia aegyptia). Toxicon 35, 141-145.

Al- Asmari A. K. 1997. Assessment of ovine antivenom raised against venom from the Arabian Cobra (Naja Haje Arabica). International Symposium on laboratory Medicine, RKH, Saudi Arabia.

Al- Asmari A. K. 1997. Snakebite syndrome in Saudi Arabia. Presented in International Symposium. International Society on Toxinology, Cuernavaca, Mexico.

Abdulrahman k. Al-Asmari, and Lena Sjostrom. (1998). Assessment of mono-specific ovine antivenom raised against Saudi Arabian venoms from Naja haje arabic, Cerastes cerastes, Echis carinatus, Echis coloratus, Bitis arietans and Atractaspis microlepidota.

International Symposium on Paris, Toxinology Society

Abdulrahman k. Al-Asmari. (2000). Scorpion sting syndrome in Riyadh, Saudi Arabia. International Symposium on Paris, Toxinology Society

Abdullah Abanamy, Abdulrhman Al-Zoman and Abdulrahman Al-Asmari. 2002. Prayer Marks. International Dermatology.

Abdulrahman K. Al Asmari, (2002). Pharmacological characterization of the rat’s paw edema induced by Echis pyramidum venom. Toxicology and applied pharmacology. D-0030.

Abdulrahman K. Al Asmari, (2002). Pharmacological characterization of the rat’s paw edema induced by Echis coloratus venom. On line Journal of biological Science, 234-OJB-2K2.

Saed Al-Ghwery and Abdulrahman K. Al Asmari, (2003). Chronic renal Failure among children in Riyadh Militrary Hospital, Saudi Arabia. J. Nephrol in press.

Department Duties:

From May, 1997. Research coordinator (senior toxinologist)

From 1999-present. Consultant immuno-toxicologist (toxinologist) and depeuty head of Research Center, Riyadh Military Hospital

From 2001-present.

. Teaching Emergency Pharmacology for EMT students

. Teaching Methods of Scientific Research for Clinicains

. Principals for projects in:

Development diagnostic immune-assay for detects species and measured the total venom concentration through circulation of envenomed patients against snakebite and scorpion stings.

Development polyclonal antibodies against different species of Malaria and optimize diagnostic assay

Development polyclonal antibodies against IgE and Histamines

Optimizing and development assays for measuring inflammations induced by toxins.

Purification and isolation of proteins, peptides and aminoacids

Development of monoclonal antibodies

Conjugated first and second antibodies

ADDITONAL INFORMATION

Member in the Journal of Venomous Animals and Toxins, Brazil

Member in International Society of Toxinology

Member in European Society of Venom Antivenom

Member in Saudi Pharmaceutical Society

Member in American Society of Health – System Pharmacists (ASHP)

Member in Saudi Arabian group for antibodies. Ministry of Health, Saudi Arabia.

Member in Biochemistry group, KFSH